Enhanced effect of recombinant IL-2 on the development of thymocytes in thymus and the recovery of immunologic functions of sublethally irradiated mice
- VernacularTitle:重组白细胞介素2促进小鼠胸腺细胞发育及辐射损伤小鼠免疫功能的恢复
- Author:
Hanlin GAO
;
Shusheng XIE
;
ET AL
;
- Publication Type:Journal Article
- Keywords:
recombinant IL-2;
thvmocvte;
immunologic function
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Sublethally irradiated BALB/c mice undergo thymic regeneration which follows a pheno-typic pattern of events similar to that observed during normal fatal development the regenerationafter irradiation is the result of a limited pool of intrathymic radioresistant stem cells.In this study we showed that 6?10~5u/kg IL-2 can accelerate the proliferation of thymo-cytes,improve the development of thymocytes from CD4~-CD8~-to CD4~+CD8~+ and CD4~+CD8~-/CD4~- CD8~+.At 30th day after irradiation,the proliferative responses of the splenocytes to ConAand LPS,the mixed lymphocyte reaction (MLR) to allogeneic spleen cells (C57BL/6),and thenumbers of plaque forming cells to SRBC were significantly enhanced in IL-2 treated mice,ascompared to that in the irradiated mice without giving IL-2.The above immune functions on day30 after irradiation were recovered to the condition of irradiated control mice on day 45,suggest-ing that the IL-2 is important cytokin in the development of thymocytes in thymus and is able toaccelerate the recovery of immune functions of irradiated mice.
