EFFECTS OF EXPERIMENTAL HYPERINSULINEMIA ON THE LEVELS OF THE MAIN APOLIPOPROTEINS AND ON THE PROCESS OF REVERSE CHOLESTEROL TRANSPORT IN RABBIT
- VernacularTitle:高胰岛素血症家兔主要载脂蛋白及胆固醇逆向转运过程的变化
- Author:
Ming-Yue ZHOU
;
Hua-Zheng ZHANG
;
- Publication Type:Journal Article
- Keywords:
Hyperinsulinemia Atherosclerosis Apolipoprotein Reverse cholesterol transport
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper presented the effects of experimental hyperinsulinemia on the main apolipoproteins (At, B) and on tbe process of reverse cholesterol transport in rabbit, which consisted of 1) uptake of cholesterol from peripheral tissue by HDL; 2) cholesterol esterification and 3) cholesterol ester transfer. The results showed that insulin could significantly decrease both serum and lymph Apo A1 levels and inhibit all the three steps of reverse cholesterol transport. The larger the dose of insulin, the greater the effects. Apo B did not seem to be influenced by insulin. It was further demonstrated by a series of statistical analyses that insulin had both direct and indirect inhibitory actions, to different extent, on each of the three main steps of reverse cholesterol transport.
