CD3 McAb Regulates human fetal thymocyte proliferative response to PHA or TPA
- VernacularTitle:CD_3McAb对PHA和TPA诱导人胚胸腺细胞增殖反应调节作用的研究
- Author:
Chuan-Shu HUANG
;
Bo-Quan JIN
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
cytokine;
monoclonal antibody;
thymocyte;
proliferation
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The regulatory effect of CD3 McAb on the human fetal thymocyte proliferative response toTPA was investigated.It was shown that the CD3 McAb couldn't induce human fetal thymo-cyte proliferative response,but suppressed PHA-induced human fetal thymocyte proliferativeresponse and promoted TPA-induced proliferative response,in a dose dependent manner.Ex-ogenous rHuIL—2,but not rHuIL—1 ,could enhance the proliferative response to CD3 McAb.These results have significances for understanding the expression of CD3 antigen and it's func-tions.
