THE EXPENMENTAL STUDY OF THE EFFECT OF DEXAMETHASON ON EXPERIMENTAL AUTOIMMUNE SENSORINEURAL NEARING LOSS
- VernacularTitle:地塞米松治疗自身免疫性感音神经性耳聋的实验研究
- Author:
Shengli LI
;
Hongliang ZHU
;
- Publication Type:Journal Article
- Keywords:
autoimmune;
sensorineural hearing loss;
acoustic brain — stem reaction threshold : inner ear hair cell;
dexamethaason
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
In this experiment, Animal model of guinea pig's experimental Autoimmune sensorineural hearing Loss was established by injecting crud inner ear antigen (CIEAg), Dexamethason was used to tret the deaf guinea pigs for one week, the ABRT(Acoustic Brain—stem Reaction Threshold) of guinea pigs was measured and the morphological change of the guinea pigs inner ear, tissue was observd. We found that the deaf guinea pig's ABRT rose distinctly to 60. 8?5.31 dBspl and inner ear hair cell showed severe damage. The number of the hair cell of the third cochlear turn lost 111?55.8. After one week treatment with Dexamethason,the treated group's ABRT reduced to 48. 8?6. 69dBspl, the number of the outer—hair—cell of the third cochlear turn is only 57. 254?18. The results indicate that Dexamethon has effect on the AISNHL,it can clearly lighten the damage of inner ear tissue and significantly improve the ABRT. The mechanism still remains unknown.
