THE RELATIONSHIP OF IMMUNOREACTIVE ?-ENDORPHIN LEVELS IN HYPOTHALAMUS, PITUITARY AND PANCREAS OF DIABETIC RATS AND THE COURSE OF DISEASE
- VernacularTitle:糖尿病大鼠下丘脑、垂体、胰腺等组织?-内啡肽含量与病程的关系
- Author:
Jing WANG
;
Jia-Qingdept ZHANG
;
- Publication Type:Journal Article
- Keywords:
Immunoreactive ?-endorphin Pain threshold Diabetes model
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Immunoreactive beta-endorphin was measured by radioimmunoassay (RIA) in the pituitary, hypothalamus, pancreas and plasma of female diabetic rats induced by streptozotocin. In addition, pain threshold was determined. The results showed that the concentrations of beta-endorphin in pituitary, hypothalamus, pancreas and plasma began to decrease on the first month after being made diabetic. Then, the levels of beta-endorphin continued to decrease significantly as the course progressed, especially in pancreas and plasma. Diabetic rats consistently showed a decreased pain threshold after 4 weeks. These results suggested that the decrease of beta-endorphin may be related to the course of diabetes and pain threshold.
