High concentration IL - 2 induces the expression of IL - 2 receptor chian on resting PBL
- VernacularTitle:高浓度rIL-2对休止PBL IL-2R_?口的诱导作用
- Author:
Xun ZHU
;
Guizhen YANG
;
- Publication Type:Journal Article
- Keywords:
IL-2;
IL-2 Receptor(?) Chain;
Resting PBL
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Using ~(125)I-labeled anti-IL-2R_? McAb, we investigated the effect of rIL-2 R_? expression . In addition to increasing the IL-2 R_? expression the actived-lymphoblasts, we found that the higher concentration of IL-2 also directly induced the IL-2 R_? expression on the resting PBL, but the peak was at the 5th day. After treated by a higher concentration of IL-2, there was a positive interrelation of time courses between the incorporation of ~3H-TdR and/or ~3H-UR and IL-2 R_? level on resting PBL. This result indicated that it was by means of inducing IL-2 R_? expression that the higher concentration IL-2 caused the proliferation of the resting PBL.
