ACTIVITIES OF SERUM SULFATION FACTOR IN PATIENTS AND MODEL RATS WITH KASHIN-BECK DISEASE
- VernacularTitle:大骨节病患者及大鼠血液硫酸化因子活性的研究
- Author:
Lizhong HOU
;
ET AL
;
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The present study referred to the incorporation of 35S-sulfate into the chicken embryo cartilage stimulated by the serum from rats fed on the grain of the endemic areas of Kashin-Beck disease (KBD) and children with KBD using the cpm /mg cartilage as the indicator of serum sulfation factor (SF) activity. The SF activity in serum from KBD model rats was markedly reduced (161.5+66.8 n= 22), when compared with the controls (212.2+58.9,n = 22). The serum SF activity in KBD children (300.5+90.9,n = 22) was much lower than that in healthy controls (425.0 + 142.5, n = 22). The results suggest that in the endemic grains and/or environment there exists certain factors which interfere with the normal function of serum SF, the change of serum SF activity may be the key-point in the pathogenesis of KBD.
