EFFECTS OF MORPHINE AND NALOXONE ON THE VENTRAL ROOT REFLEX(VRR) OF TOAD SPINAL CORD IN VITRO
- VernacularTitle:吗啡及纳洛酮对离体蟾蜍脊髓腹根反射影响
- Author:
Qiuwen FANG
;
Jun MEI
;
- Publication Type:Journal Article
- Keywords:
toad spinal cord in vitro;
ventral root reflex;
morphine;
naloxone
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of morphine and its antagnoist naloxone on the VRR were studied. Morphine, at lower concentration (3.5 ? 10~(-7)～10~(-5)M), enhanced the VRR of toad spinal cord. This effect is proportional to its concentration within certain range, even though it depressed the ARR at higher concentration (5.3?10~(-5)-8.08?10~(-5)M). When naloxone was given alone. it did not excite or depress the VRR. While the VRR was enhanced by morphine, naloxone could antagonixe the exciting effect of the former. Experiments showed that naloxone could antagonize the exciting effect on the VRR produced by morphine.
