Immunopharmacologicat Effects of Anisodamine on Immune Complex Glomerulonephritis in Rabbits
- VernacularTitle:山莨菪硷对家兔免疫复合物型肾小球肾炎的免疫药理学作用
- Author:
Lily FENG
;
Xihua ZHU
;
- Publication Type:Journal Article
- Keywords:
Anisodamine;
Acute experimerimental serum sickness;
Immune complex glomerulonephritis;
Cathepsin D;
Calmodulin.
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The immunopharmacological effects of anisodamine(654-2)on immune complexnephritis were examined in rabbits with acute experimental serum sickness(AESS).The results showed that activities of renal calmodulin(CaM)and cathepsin D(Cath-D)were significantly high.654-2 could inhibit CaM activity and immune complex-induced lysosomal enzyme release,and lessen immune complex glomerulonephritis at thesame time.Our findings suggest that a marked inhibition of CaM activity by 654-2 mi-ght contribute greatly to the improvement of immune complex glomerulonephritis.
