Effect of Tumor Promoter PMA on Cell-mediated lmmunity Ⅲ. PMA Inhibits Antigen Presentation by Spleen Adherent Cells
- VernacularTitle:促癌剂十四酰佛波乙酸酯(PMA)对细胞免疫的影响——Ⅱ.PMA抑制脾脏粘附细胞的抗原提呈功能
- Author:
Han-Zhang XIA
;
You-Hui ZHANG
;
- Publication Type:Journal Article
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
TNP-conjugated spleen adherent cells (SAC) from normal BALB/c mice could stimulate lymph-node T lymphocytes (LNT) of 1, 3, 5-trinitrobenzene (TNCB) -primed syngeneic mice to proliferate in vitro. The proliferative response was suppressed when phorbol myristic acetate.(PMA) was present in the culture. SAC pretreated with PMA also suppressed markedly the response. Furthermore, PMA was shown to inhibit interleukin-1 (IL-1) production and/or secretion by macrophages in response to LPS stimulation in vitro. Therefore, the suppressive effect of PMA on antigen presentation seems to be due to its inhibitory effect on IL-1 production and/or secretion.
