EFFECTS OF SINOMENINE ON ISOLATED GUINEA-PIG AURICLE
- VernacularTitle:青藤碱对离体豚鼠心房的作用
- Author:
Chaoxing LI
;
Gengsheng ZHAO
;
- Publication Type:Journal Article
- Keywords:
sinomenine;
auricle;
excitability
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
After Sinomenine 27 ?M was given, the contractibility was decreased to 51?11% (SD) and dT/dt max to 50?14% (SD). The automaticity induced by epinephrine was inhibited. Sinomenine (2.7-270 ?M) caused a concentration-dependent prolongation in the functional period. The amplitude of contraction and the heart rate in the right auricle was also inhibited. The results indicate that sinomenine may be antogonistic to both Ca~(++) influx and inward Na~(++) current.
