Research on the BCL I Polymorphism of Haemophilia A in Han Chinese Population in Wenzhou
- VernacularTitle:中国温州地区汉族人群甲型血友病多态性位点BCLⅠ调查
- Author:
Wan-Dong LIANG
;
Jin-Song LI
;
Yun-Tian BI
- Publication Type:Journal Article
- Keywords:
Haemophilia A;
BCL I Polymorphism;
Genetic Diagnosis
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to find the polymorphism site applicable to efficient genetic diagnosis on Haemophilia A in Han Chinese Population in Wenzhou.Methods With the method of polymerase chain reaction(PCR) and polyacrylamide gel electrophoresis(PAGE),288 of X chromosomes from 96 men and 96 women were detected on the polymorphism of BCL I in the intron 18 of FV Ⅲ gene.Results The gene frequency of the polymorphic site BCL I was 34.38% in Han Chinese population in Wenzhou.43.75% women were heterozygous and the polymorphism information content(PIC) was 0.4512.Conclusion For Han Chinese population in Wenzhou,the BCL I genetic site has enough information,being one of the genetic markers with high polymorphism,applicable to the screening for carrier and prenatal diagnosis of Haemophilia A in Wenzhou.
