Effect of Janus kinase inhibitor AG490 on the invasion of laryngeal carcinoma cells
- VernacularTitle:酪氨酸激酶抑制剂AG490对喉癌侵袭性的影响
- Author:
Xiuying LU
;
Xiaoming LI
;
- Publication Type:Journal Article
- Keywords:
Laryngeal Neoplasms;
Carcinoma,Squamous Cell;
STAT3 Transcription Factor;
Neoplasm Invasiveness
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the effect of AG490 on the invasion of Hep2 laryngeal carcinoma cells, and to investigate the role of STAT3 signaling pathway in human laryngeal carcinoma invasion.METHODS Janus kinase inhibitor AG490 was used to inhibit the activation of STAT3 signaling pathway of Hep2 cells.Hep2 cell invasion was detected by quantitative Matrigel invasion assay.The expression of p-STAT3 was measured by flow cytometry. RESULTS The activation of STAT3 signaling pathway and the invasion of laryngeal carcinomas Hep2 cell line were suppressed by AG490.The expression of p-STAT3 and the invasion cell number of Hep2 cell line in the group treated by AG490 for 24h decreased compared with that in control group(P
