Expression of SleX and CD24 in nasal inverted papilloma
- VernacularTitle:路易斯寡糖-X及CD24在鼻内翻性乳头状瘤中的表达
- Author:
Xuewei ZHU
;
Dongdong ZHU
;
Kewei SUN
;
Cuida MENG
;
Zhen DONG
;
- Publication Type:Journal Article
- Keywords:
Papilloma,Inverted;
Pathology;
Antigens,CD24;
P-Selectin;
Immunohistochemistry
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the expression of SleX and CD24 in nasal inverted papilloma and its pathologic features.METHODS HE staining were conducted to study the pathologic features in specimens of 11 cases with nasal inverted papilloma. Further,immunohistochemistry stain for SleX and CD24 were performed in total specimens.RESULTS One case(9.1%) was diagnosed as severe atypical hyperplasia but tumor cells did not invaded basal membranes.SleX staining located at cell membranes. Positive SleX staining was found in 9 specimens (81.8%) and 1 normal nasal epithelium (16.7%).CD24 staining located in cytoplasm.Positive CD24 staining was found in 8 specimens of nasal inverted papilloma (72.7%). CD24 was negative in nasal epithelial cells and only a few lymphocytes were positive.CONCLUSION Some cases of nasal inverted papilloma are diagnosed with severe atypical hyperplasia.Most of cases express CD24,so nasal inverted papilloma may be a borderline tumor.Expression of SleX and infiltration of inflammatory cells suggest that nasal inverted papilloma may be related to inflammatory reactions.
