Differentiation-inducing effects of baicalin on HL-60 leukemia cells
- VernacularTitle:黄芩苷对HL-60白血病细胞的诱导分化作用
- Author:
Bu-Yuan CHEN
;
Jian-Da HU
;
Xin-Ji CHEN
;
Lian-Huang LV
;
- Publication Type:Journal Article
- Keywords:
HL-60 cells;
Baicalin;
Cell differentiation
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the differentiation-inducing effects of baicalin on HL-60 leukemia cells.METHODS:The effect of baicalin on differential induction in AML cell line HL-60 was evaluated by cellular morphology,clone formation assay,CD11b and CD33 expression and NBT assay.RESULTS:Baicalin inhibited the proliferation of HL-60 cells.It enhanced the expression of CD11b on HL-60 cells,also increased the expression of CD33.HL-60 cells showed differentiation morphology after the drug treatment examined by Wright-Gimesa staining and NBT assay.CONCLUSION:Baicalin possessed differentiation-inducing effects on HL-60 cells.
