An experimental study on protective and therapeutic effect of oral solution of Niao Du Kang (尿毒康) on acute renal tubular necrosis of rats
- VernacularTitle:中药尿毒康对急性肾小管坏死初发期保护作用的研究
- Author:
Yan-Lin LI
;
Hai-Wen AN
;
Xiao-Hao LING
;
Jian-Hui ZENG
;
Nie-Tao GUO
;
Zhen-Yan HUANG
;
Si-You HUANG
;
Jin YANG
;
- Publication Type:Journal Article
- Keywords:
oral solution of Niao Du Kang;
acute renal tubular necrosis;
glycerin
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the preventive and therapeutic effect of oral solution of Niao Du Kang (尿毒康) on acute renal tubular necrosis (ATN) in Sprague-Dawley (SD) rats,and preliminarily approach its mechanisms.Methods The oral solution was composed of traditional Chinese medicinal herbs of Radix et Rhizoma Rhei (大黄),Radix Sanguisorbae Offieinalis (地榆),Radix Salviae Miltiorrhizae (丹参), Radix Astragali seu Hedysari (黄芪),Flos Carthami Tinctorii (红花) and so on.Sixty-four SD male rats were randomly divided into 4 groups:normal control group,ATN model group,verapamil treatment group and traditional Chinese medicine,oral solution of Niao Du Kang treatment group,every group having 16 rats.. The ATN model of SD rats was induced by intramuscular injection of 50% glycerin mixed with isotonic saline solution at the back of bilateral lower extremities.After the model was established in each group ,the levels of blood urea nitrogen (BUN),levels of blood serum creatinine (SCr),renal failure index (RFI) and renal pathological changes were detected at different time points after modeling for 12 and 24 hours,and the therapeutic effect of oral solution of Niao Du Kang was observed.Results After the model establishment, Niao Du Kang oral solution could lower the elevation of blood BUN,SCr,RFI in the model,and compared with the normal control group,there were statistical significances (all P
