Effect of Zhuyun Capsule on Expression of Ovarian Cytokine of Polycystic Ovary Syndrome Rats
- VernacularTitle:助孕胶囊对多囊卵巢综合征大鼠卵巢局部细胞因子表达的影响
- Author:
Yan-Qiao LIU
;
Hui-Min DANG
;
Run-Xia LIU
;
- Publication Type:Journal Article
- Keywords:
Polyeystic ovary syndrome;
Zhuyun Capsule(Pregnant-promoting Capsule);
Rat;
Ovarian;
Cytokine;
Sex hormone
- From:
Journal of Traditional Chinese Medicine
1993;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Zhuyun Capsule(Pregnant-promoting Capsule)on serum sex hormone and expres- sion of ovarian cytokine of polycystic ovary syndrome(PCOS)rats.Methods Progestogen plus human chorionic gonadotrophin (HCG)was adopted to make PCOS rat models.Totally 40 SD rats were randomized into control group,PCOS model group,Zhuyun Capsule group,and clomiphene citrate group with 10 in each.Radioimmune assay(RIA)was used to measure the sex hormone and immunohistochemical test was done to measure the expression of tumor necrosis factor-?(TNF-?)of ovarian tissue,insulin-like growth factors-1(IGF-1),and leukemia inhibitory factor(LIF)to analyze the relations among these factors.Results Zhuyun Capsule could reduce greatly serum testosterone(T)and luteinizing hormone(LH),decrease expression of TNF-?and IGF-1,but increase expres- sion of LIF.Conclusion Zhuyun Capsule could regulate endocrine function and expression of ovarian cytokine to improve gonad func- tions of PCOS rats and to promote the maturation of follicle and ovulation.
