Effect of Renzhu Jianwei Granules on Carcinoembryonic Antigen and Cyclooxygenase 2 of the Patients with Precancerous Lesions of Gastric Cancer
- VernacularTitle:仁术健胃颗粒对胃癌前病变患者胃黏膜癌胚抗原、环氧合酶2的影响
- Author:
Chun-Ting LI
;
Hua QIAN
;
Shu LUO
;
- Publication Type:Journal Article
- Keywords:
Precancerous lesions of gastric cancer(PLGC);
Renzhu Jianwei Granules(Granule of Semen Coicis and Rhizoma Atractylodis Macrocephalae for strengthening the stomach);
Carcinoembryonic antigen;
Cyclooxygenase 2
- From:
Journal of Traditional Chinese Medicine
1993;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Renzhu Jianwei Granules(Granule of Semen Coicis and Rhizoma Atractylodis Macro- cephalae for strengthening the stomach)on the patients with precancerous lesions of gastric cancer(PLGC)and its mechanism. Methods The 58 patients of chronic atrophic gastritis(CAG)complicated with intestinal metaplasia(IM)and/or dysplasia(Dys) were randomized into treatment group and control group with 29 in each.The treatment group was administered Renzhu Jianwei Gran- ules while the control group was given Weifuchun Tablets.The numbers of positive cells of carcinoembryonic antigen(CEA)and cy- clooxygenase 2(COX-2)of gastric mueosa before and after treatment were observed.Results The scores of positive cells of CEA and COX-2 of gastric mucosa of both groups were greatly reduced after treatment(P0.05).Conclusion Renzhu Jianwei Granules can reduce CEA and COX-2 of PLGC patients,possibly being one of the mechanisms in treating PLGC.
