Expression and their clinical significance of COX-2 and MMP-7 in laryngeal squamous cell carcinoma
- VernacularTitle:环氧化酶2和基质金属蛋白酶7在喉癌中的表达
- Author:
Gang QIN
;
Li YANG
;
Ling YU
;
Lihong WANG
;
Wanrong LI
;
Chuanyu LIANG
- Publication Type:Journal Article
- Keywords:
Laryngeal Neoplasms;
Carcinoma,Squamous cell;
Epoxy Compounds;
Matrix Metalloproteinases;
Immunohistochemistry
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the expression of cycloxygenase-2(COX-2)and matrix metalloproteinase-7(MMP-7)in laryngeal squamous cell carcinoma(LSCC)and their clinical significance. METHODS The expression of COX-2 and MMP-7 in 65 LSCC tissues and 34 adjacent non-neoplastic tissues were studied by immunohistochemical SP method. RESULTS The expression of COX-2 and MMP-7 was observed in 72.3% and 75.4% of the LSCC tissues and in 20.6% and 23.5% of the adjacent non- neoplastic tissues respectively,which had a significant difference(P
