Effects of panaxadiol saponin on TLR2 and TLR9 mRNA expression in LPS induced shock rats
- VernacularTitle:人参二醇组皂苷对LPS致休克大鼠肝脏TLR2、TLR9 mRNA表达的影响
- Author:
Zhi WANG
;
Hong-Yan LI
;
Wen-Wei LV
;
Shan-Shan LIU
;
Gui-Fang MU
;
Yang LI
;
Lian-Kun SUN
- Publication Type:Journal Article
- Keywords:
Lipopolysaccharides;
Ginseng;
Receptor,Toll-like
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the molecular mechanism of panaxadiol saponin(PDS)by observing Toll like receptor(TLR)2 and TLR9 mRNA expression induced by lipopolysaccharide(LPS).METHODS:Rats were divided into LPS,LPS+PDSL,LPS+PDSM and control group,respectively.Nitric oxide synthase(NOS)activity,nitric oxide(NO)content,LPO content,SOD activity and TLR2 and TLR9 mRNA expression were assayed 4 h after intravenous injection of LPS.RESULTS:NOS activity,NO content,LPO content of LPS+PDSL group and LPS+PDSM group were significantly lower than those in LPS group.TLR2 mRNA expression in the liver tissue of LPS+PDSL group and LPS+PDSM group was decreased compared with LPS group.CONCLUSION:PDS has a protective effect on liver tissues by triggering the down-regulation of TLR2 expression,reducing NOS activity,and NO content.
