Prophylactic Intra-Coronary Injection Nitroglycerin With Diltiazem in Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction
- VernacularTitle:预防性冠状动脉注射硝酸甘油和地尔硫对急性心肌梗死心肌微灌注影响的临床研究
- Author:
Yu WANG
;
Guoming ZHANG
;
Shaoping SU
;
Zhijun SUN
;
Lian CHEN
;
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Myocardial perfusion;
Nitroglycerin;
Diltiazem
- From:
Chinese Circulation Journal
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the influence of prophylactic intra-coronary injection nitroglycerin with diltiazem in patients of acute ST segment elevation myocardial infarction(STEMI) Methods:This study was conducted in 212 patients with acute STEMI who underwent primary percutaneous coronary inter- vention(PCI)in our center from January 2001 to December 2006.The patients were randomly assigned to receive intra-coronary nitroglycerin with dihiazem(n = 87)or none of them(125)before intervention.The clinical data,coronary angiography data after intervention,ST-segment resolution,area under the curve of CK-MB,ejection fraction(EF)and left ventricular end-diastolic di- mension several days alter operation and the major adverse cardiac events(MACE)were analyzed systemically. Results:Ten(11.5%)patients in study group and 28(22.4%)in control group had MACE(P = 0.042).The difference of re-hospitalization was also significant(19.5% vs 37.6%,P = 0.008).No/slow reflow occurred less in study group than in con- trol group,but the difference was not significant.Corrected TIMI frame count was lower(34.4?11.3 vs 38.9?17.2,P = 0.034) and myocardial blush grade was higher(2.65?0.6 vs 2.41?0.7,P =0.018)in study group.ST-segment resolution,area under the curve of CK-MB in 5 days after operation,EF and left ventricular end-diastolic dimension in study group were more significant than those in control group(P
