Effects of DNaseⅠ-treated streptococcal antigens on peripheral blood mononudear cell proliferation in patients with psoriasis vulgaris
- VernacularTitle:DNaseⅠ消化前后的链球菌抗原对寻常性银屑病外周血单一核细胞增殖反应的影响
- Author:
Yi-Hua CAI
;
Jie ZHENG
;
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Streptomyces;
DNaseⅠ;
Cell proliferation
- From:
Chinese Journal of Dermatology
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of DNaseⅠ-treated streptococcal antigens on peripheral blood mononuclear cells(PBMC)proliferation in psoriasis patients.Methods PBMC from 15 patients with psoriasis and 10 healthy controls were stimulated with three concentrations(2,10,25?g/mL) of streptococcal antigens(SA), nd DNaseⅠ-treated streptococcal antigens(DNaseⅠ-SA).After 72 h of culture,cellular proliferation was determined by ~3H thymidine incorporation.Results The DNaseⅠ-SA,at all the concentrations tested,was less potent than the corresponding concentrations of SA(P0.05),however,the lower concentrations(2,10?g/mL) of DNaseⅠ-SA were less potent than those of SA(P0.05).Also,the extent of proliferation response to SA and DNaseⅠ-SA was higher in the patients than in the controls(P
