The effect of combination treatment using palonosetron and dexamethasone for the prevention of postoperative nausea and vomiting versus dexamethasone alone in women receiving intravenous patient-controlled analgesia.
10.4097/kjae.2015.68.3.267
- Author:
Seung Hwa RYOO
1
;
Jae Hwa YOO
;
Mun Gyu KIM
;
Ki Hoon LEE
;
Soon Im KIM
Author Information
1. Department of Anesthesiology and Pain Medicine, KR Clinic, Wonju, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Dexamethasone;
Palonosetron;
Postoperative nausea and vomiting
- MeSH:
Analgesia, Patient-Controlled*;
Anesthesia;
Anesthesia, General;
Antiemetics;
Dexamethasone*;
Female;
Fentanyl;
Humans;
Incidence;
Nausea;
Pain, Postoperative;
Postoperative Nausea and Vomiting*;
Vomiting
- From:Korean Journal of Anesthesiology
2015;68(3):267-273
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The purpose of this study was to evaluate the effect of palonosetron combined with dexamethasone for the prevention of PONV compared to dexamethasone alone in women who received intravenous patient-controlled analgesia (IV-PCA) using fentanyl. METHODS: In this randomized, double-blinded, placebo-controlled study, 204 healthy female patients who were scheduled to undergo elective surgery under general anesthesia followed by IV-PCA for postoperative pain control were enrolled. Patients were divided into two groups: the PD group (palonosetron 0.075 mg and dexamethasone 5 mg IV; n = 102) and the D group (dexamethasone 5 mg IV; n = 102). The treatments were given after the induction of anesthesia. The incidence of nausea, vomiting, severity of nausea, and the use of rescue anti-emetics during the first 48 hours after surgery were evaluated. RESULTS: The incidence of PONV was significantly lower in the PD group compared with the D group during the 0-24 hours (43 vs. 59%) and 0-48 hours after surgery (45 vs. 63%) (P < 0.05). The severity of nausea during the 6-24 hours after surgery was significantly less in the PD group compared with the D group (P < 0.05). The incidence of rescue antiemetic used was significantly lower in the PD group than in the D group during the 0-6 hours after surgery (13.1 vs. 24.5%) (P < 0.05). CONCLUSIONS: Palonosetron combined with dexamethasone was more effective in preventing PONV compared to dexamethasone alone in women receiving IV-PCA using fentanyl.
