Curcumin inhibits mouse melanoma growth and influences nuclear factor?B activation and sur-vivin expression
- VernacularTitle:姜黄素对小鼠黑素瘤的抑制作用及对核因子?B激活和生存素表达的影响
- Author:
Yan-Qun LIU
;
Lin ZHOU
;
Zhi-Ping WEI
;
- Publication Type:Journal Article
- Keywords:
Melanoma,experimental;
Curcumin;
Transcription factor RelA;
Survivin
- From:
Chinese Journal of Dermatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible mechanism of curcumin inhibition to murine melanoma growth.Methods Melanoma cell line B16F10 was injected subcutaneously into the outer side of mouse right thigh to establish a melanoma-bearing mouse model.Seven days after the establishing the model, these mice were treated with intraperitoneal injection of curcumin at 50 and 100 mg/kg respectively or RPMI 1640 culture medium as control.Fourteen days later,the mice were killed,tumor weight was calculated;the tumor nuclear factor?B activity and survivin mRNA expression were measured by Western blot and RT-PCR,respectively.Results The tumor weight was significantly lower in the curcumin-treated mice than that in the controls (P
