Expression of B7-CD28/CTLA-4 in peripheral blood lymphocytes of female patients with genital condyloma acuminatum
- VernacularTitle:女性生殖道尖锐湿疣患者外周血淋巴细胞B7-CD28／CTLA-4的表达及意义
- Author:
Li-Ming RUAN
;
Wei WU
;
Yi-Na WANG
;
Xiao-Yan LIU
;
Xiao-Ling JIANG
;
Hong-Chao CHEN
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
Papillomavirus,human;
T-lymphocytes;
Antigens,CD28;
Antigens,CD152;
Antigens,CD80;
Antigens,CD86
- From:
Chinese Journal of Dermatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of B7-CD28/CTLA-4 (CD152),co-stimulatory molecules of T lymphocytes,in the onset,development and prognosis of genital congdyloma acuminatum (CA) in females.Methods Flow cytometry was utilized to detect the expression levels of CD80/CD86 in peripheral blood lymphocytes and of CD28/CD152 (CTLA-4) in CD4~+/CD8~+ T lymphocytes from 30 CA patients (17 primary CA,13 recurrent CA,15 at recovery stage of CA) and 15 healthy volunteers as con- trols.Results No significant difference was found for the frequencies of CD80~+,CD86~+,CD4~+/CD28~+ and CD8~+/CD28~+ lymphocytes between the primary or recurrent group and the control group.The frequencies of CD8~+/CD28~+,CD4~+/CD28~+ and CD80~+ lymphocytes were significantly higher in the recovery group than those in the recurrent group (P0.05).Conclusions There is an abnormal expression of co-stimulatory molecules B7-CD28/CTLA-4 (CD152) in periphoral blood lym- phocytes,CD4~+ and CD8~+ T lymphocytes in female patients with genital CA,and the expression abnormaility is closely linked with different disease stages of CA.
