Expression of CD147,cyclophilin A and cyclophilin B in psoriatic lesions
- VernacularTitle:银屑病患者皮损中CD147、亲环素A和亲环素B的表达
- Author:
Xiang CHEN
;
Juan LI
;
Juan SU
;
Yi-Xi WU
;
Jing CHANG
;
Sheng PENG
;
Ye-Hong KUANG
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Antigens,CD147;
Cyclophilins;
T-lymphocytes;
Neutrophils
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and pathologic significance of CD147,cyclophilin A (CyPA)and cyclophilin B(CyPB)in psoriatic lesions.Methods Immunohistochemical method was ap- plied to detect the expression of CD147,CyPA and CyPB in skin specimens of 15 patients with psoriasis pustulosa(PP),20 patients with progressive psoriasis vulgaris(PPV),and 20 patients with inactive psori- asis vulgaris(IPV).Immunoreactivity intensity distribution index(IRIDI)was calculated to assess the expres- sion intensity of CD147,CyPA and CyPB.Results CD147,CyPA and CyPB were detected in all speci- mens.The IRIDI scores of CD147 and CyPA were significantly higher in keratinocytes of psoriatic lesions than in those of the control specimens(all P0.05).The IRIDI score of CyPB in T lymphocytes of PP lesions was significantly elevated than that in PPV lesions,which was in turn higher than that in IPV lesions(all P0.05).Conclusion CD147,CyPA and CyPB may play a role in the occurrence and development of psoriasis.
