Skp2 and p27 protein expression and their significance in laryngeal squamous cell carcinoma
- VernacularTitle:喉鳞状细胞癌中Skp2和p27蛋白的表达
- Author:
Jianfeng GUO
;
Fujin CHEN
;
Zhiwei GUAN
;
Yanfeng CHEN
;
Qiuli LI
;
Dian OUYANG
- Publication Type:Journal Article
- Keywords:
Laryngeal Neoplasms;
Carcinom Squamous Cell;
S-Phase Kinase Associate Proteins;
Cyclin-Dependent Kinase Inhibitor p2 Immunohistochemistry
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the correlation of S-phase kinase associated protein 2 (Skp2) and p27 expression with the clinical factors and prognosis of patients with laryngeal squamou cell carcinoma (LSCC). METHODS The expressio of Skp2 and p27 in 79 specimens of LSCC and 1 specimens of adjacent normal laryngeal mucos tissues were evaluated by SP immunohistochemist methods. RESULTS The overexpression rate Skp2 was significantly higher in LSCC(53.16 %) tha in adjacent normal laryngeal mucosa tissue (0 % (P
