Production Technology of Ceftizoxime Sodium
- VernacularTitle:头孢唑肟钠生产工艺及条件的研究
- Author:
Meiying HUANG
;
Kai LUO
;
Tingzhang HU
;
Xing XIA
;
Kezhong LIANG
;
JUNSHENG
- Publication Type:Journal Article
- Keywords:
Ceftizoxime sodium;
Synthesis;
Technical parameter;
Study
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the production process of ceftizoxime sodium.METHODS:Ceftizoxime acid was prepared with 7-Amino-3-norcephem-4-carboxylic acid(7-ANCA)and AE-ester ceftizoxime acid as raw material;then ceftizoxime sodium was obtained through the reaction between ceftizoxime acid and sodium carbonate.The effects of parameters including reaction time,and amount and dripping velocity of ethanol,the amount of sodium carbonate,and pH of solution on quality of product were studied.RESULTS:The reaction process could be realized successfully.The optimal parameters for the synthesis of ceftizoxime sodium were as follows:reaction time=1.5h,the velocity of dripping ethanol=400mL? h-1,reaction temperature
