Bugu capsules prevent glucocorticoid-induced osteoporosis or bone loss in SLE patients
- VernacularTitle:补骨胶囊预防糖皮质激素所致系统性红斑狼疮患者骨质疏松或骨量减少的研究
- Author:
Qiu-Xia CHEN
;
Jian-Qiang SHI
;
CHANG-XING
;
Bin ZHOU
;
Mong-Mei QIN
;
Tie WU
;
Zhi-Hua WU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus;
systemic;
Osteoporosis;
Bugu capsules
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevention of glucocorticoid-induced osteoporosis or bone loss in systemic lupus erythematosus (SLE) patients by Bugu capsules.Methods Sixty-six patients with SLE were randomly divided into A and B groups:34 patients in Group A were treated by glucocorticoid and Bugu capsules,and 32 patients in Group B by glucocorticoid alone.All patients were measured for bone mineral density (BMD) in Wards triangle,and for related biochemical parameters such as serum calcium, phosphonium,alkaline phosphatase,parathyroid hormone (PTH) and interleukin-6 (IL-6) before and after the treatment.As the control group,thirty healthy subjects were measured for the above parameters.Results There was significant difference in the serum level of IL-6,calcium and PTH between the Group B and con- trol group (P＜0.01).The occurrence rate of osteoporosis or bone loss in group A was significant lower than that in group B [2/34 (5.88%) vs 9/32 (28.13%),P=0.0364].Conclusion Bugu capsules can prevent glucocorticoid-induced osteoporosis or bone loss in SLE patients,possibly by restoring the balance among serum IL-6,calcium and PTH.
