Effect of pregnancy uterine microenvironment on the expression of NKG2A,NKG2D and their ligands in decidual NK cells
- VernacularTitle:妊娠子宫微环境中uNK细胞NKG2A和NKG2D及其配体表达的研究
- Author:
Li-Li ZHAO
;
Xun QU
;
Lu LIANG
;
Mei-Xiang YANG
;
Bei-Hua KONG
;
Bai-Hua DONG
;
Xiao-Mei LV
;
You-zhong ZHANG
;
Xiao-xia BAI
- Publication Type:Journal Article
- Keywords:
Decidua;
Killer cells,natural;
Pregnancy
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of NKG2A,NKG2D and their ligands in pregnancy uterine micro-environment and to probe the function of NKG2A and NKG2D imbalance expression during the immunotolerance at the fetal-maternal boundary.METHODS: Decidual lymphocytes and peripheral lymphocytes were obtained from 30 women during 6-9 weeks of pregnancy who were undergoing selective termination.FACS technology was used to detect NK cells number and NKG2A,NKG2D expression.RT-PCR was used to investigate HLA-E and MICA mRNA in trophoblast tissue.RESULTS: Natural killer cells predominate,accounting for 70% of pregnancy endometrial lymphocytes.FACS results indicated that NKG2A was significantly increased in decidual NK cells as compared with that in peripheral NK cells,accounting for 97.86%?1.75% and 33.35%?10.92%.The difference between them in NKG2A expression was significant(P
