Effect of remifentanil on calcium-activated potassium currents in human mesenteric arterial smooth muscle cells
- VernacularTitle:瑞芬太尼对人肠系膜小动脉平滑肌细胞钙激活钾电流的影响
- Author:
Peng-Tao LIN
;
Da-Qing LIAO
;
Nan-Fu LUO
;
Jin LIU
- Publication Type:Journal Article
- Keywords:
Piperidines;
Mesenteric arteries;
Muscle,smooth,vascular;
Potassium channels,calcium-activated
- From:
Chinese Journal of Anesthesiology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the ionic mechanism of remifentanil-induced vaso-relaxation by recording calcium-activated K~+-currents(IKCa)in human arterial smooth muscle cells(MASMCs).Methods Human MASMCs were obtained freshly by the method of enzymolysis.IKCa were separated with 4-AP 5 mmol?L~(-1) and recorded by the whole-cell voltage-clamped technique.The effects of remifentanil(1.2,4.8,19.4 mmol?L~(-1))on amplitude and threshold of activation for IKCa were assessed.Results Remifentanil significantly increased IKCa and had no effect on the threshold of activation for IKCa as compared with the control group(P＜0.05 or 0.01),and the IKCa returned to the baseline level after remifentanil was washed out.Conclusion Remifentanil produces vasodilation by activating IKCa in MASMCs.
