Expression and significance of PTEN in esophageal squamous cell carcinomas
- VernacularTitle:抑癌基因PTEN在人食管鳞癌中的表达及其意义
- Author:
Hui ZHAO
;
Bo CONG
;
Shu-Hua PENG
;
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Genes;
Prognoses
- From:
Chinese Journal of Digestive Endoscopy
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study on the relationship of PTEN with clinicopathological parameters and prognosis of esophageal squamous cell carcinoma patients.Methods The expression of PTEN was detected in 62 cases of esophageal squamous cell carcinomas by immunohistochemistry.Results(1)PTEN expres- sion is negatively correlated with the depth of invasion,lymph node metastasis,distant metastasis,pTNM stage and degree of differentiation.(2)The difference of survival is significant between high and low expres- sion groups.Conclusion PTEN is correlated negatively with the clinicopathological parameters reflecting the malignant biological behavior,and is one of the significant prognostic predictors by univariate analysis.
