Effect of Jiannao Decoction on Cerebral Nerve Cell Apoptosis of SHRsp Model Rat after Stroke
- VernacularTitle:健脑方对SHRsp大鼠卒中后脑神经细胞凋亡的防治作用
- Author:
Shaojie WANG
;
Wen BAI
;
Chunling WANG
;
- Publication Type:Journal Article
- Keywords:
Pituitary stroke/TCM therapy;
Apoptosis/drug action;
@ Jiannao Decoction
- From:
Journal of Traditional Chinese Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe changes of cerebral nerve cell apoptosis of the rat after acute stroke and the preventive and treating effect of Jiannao Decoction on the apoptosis.Methods:SHRsp rats were used to establish the model of acute stroke,which were treated with Jiannao Decoction.Symptoms and signs of the nervous system and changes of pathological structures of the hipocampus were investigated before and after establishment of the model,and changes of cerebral nerve cell apoptosis before and after establishment of the model and medication were investigated with TUNEL,immunohistochamical and Western blot methods. Results:The incidence rate of stroke in the prevention group was significantly lower than that of the model group(P0.05).Conclusion:Jiannao Decoction has significant protective action on brain in the rat with stroke,which is related with inhibiting the effect of nerve cell apoptosis and conduction of apoptosis-related signals.
