Study on Correlativity of Senile Dementia of Type of Deficiency of Kidney Essence with Polymorphophism of APOE Gene
- VernacularTitle:肾精亏虚型老年痴呆与APOE基因多态性的相关性研究
- Author:
Lan ZHOU
;
Yongnian HU
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease/genetics;
deficiency of kidney/genetics
- From:Journal of Traditional Chinese Medicine
1992;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore correlativity of senile dementia of deficiency of kidney essence with polymorphophism of APOE gene. Methods:41 cases of senile dementia and 85 healthy aging persons were divided into 3 TCM syndrome types:syndrome of deficiency of kidney essence,syndrome of orifices confused by phlegm,and syndrome of obstruction of blood stasis in collaterals. DNA in white blood cells was isolated by NaI,and APOE gene was detected by milti-ARMs PCR,and then correlative analysis was made.Results:(1)There was a significant difference between the dementia group and the control group in the gene type ?3/ ?3(P1.(3)There was significant correlativity between syndrome of deficiency of kidney essence and APOE ?4 allelic gene(P
