Effect of Allopurinol on the Function of Blood Vessel Endothelium in Patients with Essential Hypertension Complicating Hyperuricemia
- VernacularTitle:别嘌呤醇对原发性高血压合并高尿酸血症患者血管内皮功能的影响
- Author:
Xizhu WANG
;
Yuexia SONG
;
Qiaofeng SONG
;
Li'Na ZHANG
;
Hongjuan JIA
;
- Publication Type:Journal Article
- Keywords:
Allopurinol;
Essential hypertension;
Hyperuricemia;
Endothelium function
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the effect of allopurinol on the function of blood vessel endothelium in patients with essential hypertension complicating hyperuricemia. METHODS: 65 cases with essential hypertension complicating hyper uricemia were randomized into treatment and control group. The control group was given the classic non- pharmacotherapy: reduced intake of sodium, more exercise, weight loss etc. The treatment group was treated wilh 100mg allopurinol b.i .d for 4 weeks besides the classical non - pharmacotherapy as stated for the control group. Serum uric acid level, brachial artery flow -mediated diastolic (FMD) function, the base internal diameter of brachial artery, nitrogen oxide (NO), von Willebrand' s factor(vWF) were compared between two groups before and after treatment. RESULTS: As compared with prior treatment, the treatment group had decreased level of uric acid and decreased vWF level, increased level of NO and a significantly increased level of FMD, all had statistical significances(P0.05) . CONCLUSION: Allopurinol can ameliorate the function of blood vessel endothelium in patients with essential hypertension complicating hyperuricemia.
