Distribution of Human CYP3A Activity in 544 Children at School Age in Shanghai
- VernacularTitle:上海市544例学龄儿童CYP3A酶活性分布初探
- Author:
Jian ZHANG
;
Xiaodong ZHU
;
Min'Gang WEI
;
Yuenian TANG
;
Yuelian JIANG
;
Lun CHEN
;
Haitao LIU
- Publication Type:Journal Article
- Keywords:
CYP3A;
Hydrocortisone;
Sex;
HPLC;
Urine
- From:
China Pharmacy
2005;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a scientific evidence for evaluation of individualized administration among children.METHODS:Hydrocortisone probe was used for determination of CYP3A activity in children with quantitative method.RESULTS:CYP3A activity in the health children volunteers showed Gaussian distribution in the form of natural logarithm,the average value was1.69?1.04,with the value of1.63?0.99in males and1.75?1.09in females.CONCLUSION:There is no significant difference in CYP3A activity between the two sexes.
