Predictive Factors for Valproate Treatment in Childhood Absence Epilepsy.
- Author:
Geun Ha CHI
1
;
Tae Gyu HWANG
Author Information
1. Department of Pediatrics, College of Medicine, Inje University, Busan, Korea. htg6700@chollian.net
- Publication Type:Original Article
- Keywords:
Valproate;
Epilepsy;
Absence;
Remission
- MeSH:
Demography;
Epilepsy;
Epilepsy, Absence;
Humans;
Logistic Models;
Seizures;
Triazines;
Valproic Acid
- From:
Journal of the Korean Child Neurology Society
2010;18(1):7-13
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To determine the clinical and demographic factors associated with long-term remission of valproate(VPA) therapy in childhood absence epilepsy. METHODS: Fifty-six cases of childhood and juvenile absence epilepsy were identified by reviewing of Electroencephalographic records and medical charts. Thirty-six cases were initially treated with VPA. Factor associated with responsiveness were identified by uni- and mutivariate logistic regression. RESULTS: Twenty-seven patient achieved long-term remission(75%). Failure to achieve remission was more likely if the initial treatment of VPA had failed than if it was successful(53% versus 90.4%, P<0.02) was also associated with failure of long-term remission. Lamotrigine was more efficacious add-on drug than Ethosuximide(63.6% vs 25% P=0.04). CONCLUSION: Long-term seizure remission was related to the patient's initial response to VPA.
