Genetic Epidemiology of Alopecia Areata in Chinese Hans
- VernacularTitle:皖籍汉人斑秃的遗传流行病学研究
- Author:
Jie YANG
;
Sen YANG
;
Jiang-Bo LIU
;
Hong-Yan WANG
;
Liang-Dan SUN
;
Yan-Hua LIANG
;
Xue-Jun ZHANG
- Publication Type:Journal Article
- Keywords:
Alopecia areata;
Genetic epidemiology
- From:
Chinese Journal of Dermatology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the genetic epidemiologic features of alopecia areata (AA) patients in China and to presume the possible genetic mo del of AA.Methods A case-controlled study of 1032 AA patients was performed to analyze the effect of genetic factors on the liability to AA.Complex segreg ation and heritability analysis were performed using Falconer's method and SAGE-REGTL programs.Results The mean age of onset was 28.98 ? 13.43 years.The d ifference in the mean age of onset was not significant between males and females.A total of 82.6 percent of patients experienced their first episode of AA befo re the fourth decades of life.A positive family history of AA was obtained in 8 7 patients (8.43%).The prevalences of AA were 1.58%,0.19% and 0.03% in the firs t-,second-and third-degree relatives of the probands respectively,which were significantly higher than those in the controls(P
