Preventive Effect of Emodin and Astragalus Polysaccharides on Experimental Hepatocarcinoma in Rats
- VernacularTitle:大黄素、黄芪多糖对大鼠实验性肝癌的预防作用
- Author:
Lichao YUAN
;
Yan'An CHENG
;
Shuangsuo DANG
;
Zhengguo ZHANG
;
Yunru CHEN
;
Xiaoli JIA
- Publication Type:Journal Article
- Keywords:
Emodin;
Astragalus polysaccharides;
Hepatocellular carcinoma;
Rat
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the preventive effect of emodin and astragalus polysaccharides on experimental hepato-carcinoma in rats.METHODS:The experimental rats were randomly divided into the normal group,model group,emodin group,and emodin combined with astragalus polysaccharides group.hepatocarcinogenesis in rat models were induced by di-ethylnitrosamine,while at the same time all the groups were administered with pre-set drugs by stomach irrigation.Rat's we_ ight,serum indices of ALT,ALP,?-GT,?-L-fucoxidase were determined,and pathological examination was made before and after administration.RESULTS:The group administered with emodin and astragalus polysaccharides improved more than any other groups in terms of rat's weight,serum indices,onset time of hepatocarcinogenesis,and pathological grade.CONCLU_ SION:Emodin combined with astragalus polysaccharides have certain preventive effect on experimental hepatocarcinoma in rats.
