Pharmacodynamic Comparison between Fast-disintegrating Oral Nitroglycerin Tablets and Commercial Tablets
- VernacularTitle:硝酸甘油口腔速崩片与市售含片药效学比较
- Author:
Lan CHEN
;
Xin'An WU
;
Xiaodong GUO
;
- Publication Type:Journal Article
- Keywords:
Nitroglycerin;
Fast-disintegrating oral tablet;
Commercial tablet;
Heart rate;
Diastolic blood pressure
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate clinical pharmacodynamics between fast-disintegrating oral nitroglycerin tablets and commercial tablets.METHODS:Fast-disintegrating oral nitroglycerin tablets with the same content as commercial tablets were prepared,the effects of two kinds of tablets on diastolic blood pressure,heart rate of the healthy volunteers were observed and compared.RESULTS:Fast-disintegrating oral nitroglycerin tablets showed more rapid drug absorption than the commercial tablets3minutes after administration,there was remarkable difference between them(P
