A study of hepatocyte apoptosis and its gene expression in patients with liver cirrhosis and portal hypertension
- VernacularTitle:肝硬变门静脉高压症患者肝细胞凋亡与原癌基因表达的研究
- Author:
Yukuang YAN
;
Haifeng PENG
;
Nengying LIU
;
Dening LI
;
Junying DUAN
;
Zhen YANG
- Publication Type:Journal Article
- Keywords:
LIVER CIRRHOSIS/compl;
HYPERTENSION,PORTAL/etiol;
APOPTOSIS;
GENES EXPRESSION
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of hepatocyte apoptosis and gene expression of liver cirrhosis and primary hepatic carcinoma. Methods Specimens of liver tissue from patients with liver cirrhosis and portal hypertension and normal subjects were examined by transmission electron microscope to detect apoptotic cells and primary cancer gene expression. Results The number of apoptotic cells and the apoptotic index of cirrhotic liver tissue was higher than that of normal subjects.Immunostaining of bcl 2,c myc,c fos was negative in normal liver tissue ,but was over expressed in cirrhosis. Conclusions Hepatocyte apoptosis plays a certain role in the development of hepatic cirrhosis. The oncogenes bcl 2,c myc,c fos take part in the regulation of hepatocyte apoptosis .
