Distribution of CD68+ Monocytes/Macrophages in Human Normal Dermis
- VernacularTitle:成人正常皮肤CD68阳性单核-巨噬细胞分布的研究
- Author:
Yingjun GUO
;
Yuming ZHAO
;
Yakun WANG
;
Yi XIAO
;
Qun WEI
;
Hongduo CHEN
- Publication Type:Journal Article
- Keywords:
Dermis;
Monocytes;
Macropages
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distribution, morphology and density of CD68+ monocytes/macro,phages in normal human dermis. Methods Normal skin specimens from 6 sites including face, trunk, proximal limbs, distal limbs, palms and soles of 8 adults were collected. The epidermal sheets, horizontal and longitudinal sections of the specimens were stained with an ABC immunoperoxidase procedure with anti-CD68 monoclonal antibodies. Results The CD68+ cells were detected within the superficial dermis with various densities: 562 ? 230/mm2 at distal limbs, 517 ? 162/mm2 at trunk, 509 ? 235/mm2 at face, 507 ? 192/mm2 at palms, 472 ? 138/mm2 at proximal limbs and 361 ? 78/mm2 at soles. Lower densities of CD68+ cells with dendritic morphology were found in the deep (reticular) dermis, and dispersed among collagen bundles. Conclusions There are CD68+ monocytes and macrophages in the superficial dermis, forming a relatively dense network of defense. Such a distribution might indicate the clear polarity of the CD68+ monocytes/macrophages in the dermis, with their direction of defense towards the dermal-epidermal junction.
