Establishment and assessment of a model of abdominal postoperative fatigue syndrome in rats
- VernacularTitle:腹部术后疲劳综合征大鼠模型的建立及其评价
- Author:
Jianxin YANG
;
Ming YANG
;
- Publication Type:Journal Article
- Keywords:
ABDOMEN/surg;
POSTOPERATIVE FATIGUE SYNDROME;
HEPATECTOMY;
DISEASE MODELS,ANIMAL
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish and assess a model of abdominal postoperative fatigue syndrome (POFS) in rats. Methods After 70% hepatectomy was performed, the following observations of the animals were made:general condition, rat tail suspension test,weight carrying swim fatigue test,serum levels of albumin,ferrition,and iron,pathologic assessment of injury of small intestinal mucosa and hepatic albumin gene expression .Results After 70% hepatectomy of the rats,their general candition was poor,the level of physical tolerance decreased,they showed a certain amount of depression,and marked changes were found in nutritional index,stress injury of small intestinal mucosa and hepatic albumin gene expression.Conclusions A 70% hepatectomy rat model has the basic characteristics of clinical abdominal POFS, and can be used as an experimental animal model for the study of abdominal POFS.
