Analysis of insulin and C-peptide releasing test in women with abnormal glucose metabolism during pregnancy
- VernacularTitle:妊娠期糖代谢异常患者胰岛素和C肽释放试验的分析
- Author:
Jun LIAO
;
Yuqin ZHOU
;
- Publication Type:Journal Article
- Keywords:
Diabetes, gestational;
C-peptide;
Insulin
- From:
Chinese Journal of Perinatal Medicine
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of plasma insulin and C peptide level in women with gestational diabetes mellitus(GDM), gestational impaired glucose tolerance(GIGT) and normal pregnant and to find out the patterns of glucose metabolism in pregnancy and the function of islet ? cell in patients with gestational impaired glucose metabolism Methods Thrity one normal pregnant women (group Ⅰ), 36 GIGT (group Ⅱ)and 31 GDM (group Ⅲ) were selected. Insulin and C peptide levels were measured by radioimmunoassay. Results Insulin and C peptide levels of groups Ⅰand Ⅲ increased with the gestational age and decreased at postpartum. At 31 weeks of gestation, insulin and C peptide levels of group Ⅱ and group Ⅲ were significantly higher than that of group I [insulin: (13.95?3.15) mIU/L and (15.10?2.96)mIU/L vs (11.40?3.27) mIU/L; C peptide: (0.60 ?0.21) pmol/ml and (0.80?0.31) pmol/ml vs (0.44?0.26) pmol/ml, P 0.05). The peak value of insulin and C peptide was found at the first hour postprandially in group I, while at the second hour in group Ⅱ and Ⅲ. Conclusions Insulin resistance during pregnancy becomes stronger gradually with pregnant progress. Women with abnormal glucose metabolism during pregnancy would have more insulin resistance which leads to the damage of insulin secretion. These women should have long term followed up.
