The evaluation of Survivin protein expression for the prognosis of postoperative patients with hepatocellular carcinoma
- VernacularTitle:凋亡抑制蛋白Survivin的表达与肝细胞肝癌预后的关系
- Author:
Hong CHANG
;
Taihuang WU
;
Qingling MU
;
Leping LI
;
Xiaohua PAN
;
Changqing JING
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Prognosis;
Survivin gene;
COX proportional hazards model
- From:
Chinese Journal of General Surgery
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the correlation between the expression of Survivin、VEGF and MMP 2 and the prognosis of patients with hepatocellular carcinoma Methods Expressions of Survivin、 VEGF and MMP 2 were detected by immunohistochemical S P method in 67 postoperative HCC cases Twelve candidate factors associated with long term survival were analyzed by Kaplan Meier Log rank estimation A multivariative Survival analysis of these individual variables was undertaken using the cumulative survival rate by the COX proportional hazards model Results A multivariative analysis determined three independent significant factors influencing overall cumulative survival including Survivin, VEGF, liver function (Child grade) The three prognostic factors predicted an increased risk of death from HCC Conclusion Survivin, VEGF, liver function, particularly the Child Pugh classification are the most significant prognostic factors for HCC patients undergoing hepatic resection
