Inhibition of low molecular weight heparin on the growth and metastasis of human hepatocarcinoma implanted in nude mice
- VernacularTitle:低分子肝素对肝癌生长和转移抑制作用的研究
- Author:
Yu WANG
;
Qi ZHENG
;
Jun YAN
;
Zhaoyou TANG
;
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Neoplasm metastasis;
Heparins;
Angiogenesis inhibitor
- From:
Chinese Journal of General Surgery
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of low molecular weight heparin on the growth and metastasis of hepatocarcinoma in vivo Methods Metastatic model simulating human hepatocarcinoma was established by orthotopic implantation of the tumor tissue into nude mice Animals were randomly divided and submitted to different treatment groups: control group treated with nornal saline, chemotherapy group with 5 FU and CDDP i p , Fragmin group (low molecular heparin), combination group After 5 weeks of treatment, tumor volume、 microvessel density (MVD)、 VEGF smoothmuscle actin (SMA) and metastasis in Fragmin group significantly decreased and tumor inhibitive rate increased ( P
