Expression of Mage-A1、A2、A3 in breast cancer tissue and breast cancer cell lines
- VernacularTitle:Mage-A1、A2、A3在乳腺癌组织及乳腺癌细胞株中表达的研究
- Author:
Quan MA
;
Ping FAN
;
Wei ZHENG
;
Xuanyi WANG
;
Zhengyan WU
;
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Gene expression;
Cells
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of Mage A1、A2、A3 in breast cancer tissues and four breast cancer cell lines Methods The expression of Mage A1、A2、A3 in breast cancer tissues and four breast cancer cell lines, MCF 7、Sk Br 3、MDA MB 435s and TM40D was detected by reverse transcription polymerase chain reaction (RT PCR) Results The positive expression rate of Mage A in breast cancer tissues was 13/33 (39%), of Mage A1 was 4/33 (12%), of Mage A2 was 8/33 (24%), and of Mage A3 was 7/33 (21%), respectively Both Mage A1 and Mage A3 were positive in breast cancer cell line MCF 7 and Sk Br 3 MDA MB 435s expressed Mage A2 and Mage A3 Mage A3 was positive in TM40D Conclusion Mage genes were often expressed in breast cancer, but expression of Mages varies in the breast cancer cell lines Mage genes encoding proteins are eligible for Mage peptide based active immunotherapy
