Expression of angiotensin Ⅱ type 1 receptor and angiotensinogen in preeclamptic placenta
- VernacularTitle:妊高征患者胎盘组织血管紧张素Ⅱ1型受体和血管紧张素原的表达
- Author:
Yiling DING
;
Ling YU
;
Yan HU
;
Al ET
- Publication Type:Journal Article
- Keywords:
Pregnancy complication,cardiovascular;
Hypertension;
Receptors, angiotensin;
Angiotensinogen
- From:
Chinese Journal of Perinatal Medicine
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the significance of renin angiotensin system (RAS) expressed on placenta in pregnancy induced hypertension (PIH). Methods The expression of placental angiotensin Ⅱtype 1 receptor (AT 1R) and angiotensinogen (AGT) in patients with PIH ( n =20) were investigated and compared with controls ( n =15) using immunohistochemistry and semi quantitative reverse transcription polymerase chain reaction (RT PCR). Results AT 1R was mainly found in the syncytiotrophoblasts, cytotrophoblasts,the vascular endothelial cells and smooth muscle cells. The expression of AT 1R in PIH group (112.43?11.75) was higher than that of control group (170.47? 10.59) ( P
