Study of the toxicity of topiramate on embryonic development in rats
- VernacularTitle:抗癫癎药妥泰对大鼠胚胎发育毒性的研究
- Author:
Cong LUO
;
Rongna REN
;
Yuhua HU
;
Al ET
- Publication Type:Journal Article
- Keywords:
Fructose;
Antiepileptic drug;
Toxicity tests;
Fetal growth restriction;
Rats
- From:
Chinese Journal of Perinatal Medicine
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the toxicity of topiramate (TPM), an antiepileptic drug, on embryonic development in rats. Methods Fifty one female pregnant rats were divided into five groups. TPM 40 mg/kg, TPM 80 mg/kg and TPM 40 mg/kg+ valproate acid( VPA) 300 mg/kg were given to group A,B and C respectively by gavage on day 6～15 through gestation. The negative control group(D) were administered with distilled water and the positive control group(E) were treated with cyclophosphomide (CP) (10 mg/kg on day 11, ip). All animals were sacrificed on day 20. The survival, dead and absorbed fetus was calculated. The parameters of embryonic and fetal development were analyzed and external abnormality was examined. Results Maternal body weight gain in group A,B and C [(89.6?16.5) g, (74.8?10.7) g, (91.5?20.3) g] was significantly lower than that of group D [(109.5?14.2) g ( P
