Artificial liver support and liver transplantation for the treatment of severe hepatitis
- VernacularTitle:人工肝支持系统联合肝移植治疗晚期重型肝炎的临床经验
- Author:
Shusen ZHENG
;
Xiao XU
;
Lanjuan LI
;
Tingbo LIANG
;
Feng GAO
;
Weilin WANG
;
Qian YANG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Liver, artificial;
Treatment modality
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To sum up the experience of application of artificial liver support system (ALSS) combined with liver transplantation(LT) in the treatment of end stage severe hepatitis.Methods Clinical data of 23 patients with end stage severe hepatitis receiving ALSS treatment prior to liver transplantation among 223 patients who underwent LT consecutively between April 1993 and December 2003 were analyzed retrospectively. Twenty three patients with end stage severe hepatitis received 58 courses of ALSS prior to liver transplantation. The 6 month survival rate was compared to those in non ALSS non LT group and non LT group.Results ALSS treatment facilitated improvement of liver function, endotoximia, and the tolerance to LT, thus provided a bridge time for attaining the donor liver. The total serum bilirubin level at LT was significantly lower than that before the first run of ALSS ( P
